Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cefoselis Sulfate (FK 037 Sulfate) 是一种头孢菌素 β-内酰胺抗生素。它对多种革兰氏阳性和革兰氏阴性生物均表现出良好的活性。它可以透过血脑屏障。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 537 | 现货 | ||
10 mg | ¥ 825 | 现货 | ||
50 mg | ¥ 2,360 | 现货 | ||
100 mg | ¥ 3,996 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 747 | 现货 |
产品描述 | Cefoselis Sulfate (FK 037 Sulfate) is a widely used beta-lactam antibiotic. |
体外活性 | Cefoselis inhibits GABA-induced currents in a concentration-dependent manner with IC50 of 185 mM. [1] Cefoselis possesses a superior antistaphylococcal activity on MSSA isolates to both other compounds being however equal active to Cefepime and Cefpirome on multiresistant enterobacteriaceae. [2] Cefoselis is dose-dependently appeared in brain extracellular fluid in proportion to its blood level. [3] Cefoselis, a new parenteral cephalosporin, is active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. [4] |
体内活性 | Cefoselis elicits a massive elevation of extracellular glutamate concentration in normal rats. [3] Cefoselis (50 mg/animal)-induced convulsions are prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0.78, 1.59 and 33.0, respectively), but not by carbamazepine or phenytoin. [5] |
别名 | FK 037 Sulfate, FK-037, 硫酸头孢噻利 |
分子量 | 620.64 |
分子式 | C19H22N8O6S2·H2SO4 |
CAS No. | 122841-12-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (44.31 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6112 mL | 8.0562 mL | 16.1124 mL | 40.281 mL |
5 mM | 0.3222 mL | 1.6112 mL | 3.2225 mL | 8.0562 mL | |
10 mM | 0.1611 mL | 0.8056 mL | 1.6112 mL | 4.0281 mL | |
20 mM | 0.0806 mL | 0.4028 mL | 0.8056 mL | 2.0141 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cefoselis Sulfate 122841-12-7 Microbiology/Virology Antibacterial Antibiotic Cefoselis cephalosporin Gram-negative Gram-positive Bacterial FK 037 barrier FK 037 Sulfate FK037 FK-037 FK037 Sulfate Inhibitor β-lactam organisms 硫酸头孢噻利 blood-brain FK-037 Sulfate inhibit inhibitor